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25 September 2015 Intrinsic optical signal imaging of retinal physiology: a review
Xincheng Yao, Benquan Wang
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Journal of Biomedical Optics, Vol. 20, Issue 9, 090901 (September 2015). https://doi.org/10.1117/1.JBO.20.9.090901
Abstract
Intrinsic optical signal (IOS) imaging promises to be a noninvasive method for high-resolution examination of retinal physiology, which can advance the study and diagnosis of eye diseases. While specialized optical instruments are desirable for functional IOS imaging of retinal physiology, in depth understanding of multiple IOS sources in the complex retinal neural network is essential for optimizing instrument designs. We provide a brief overview of IOS studies and relationships in rod outer segment suspensions, isolated retinas, and intact eyes. Recent developments of line-scan confocal and functional optical coherence tomography (OCT) instruments have allowed in vivo IOS mapping of photoreceptor physiology. Further improvements of the line-scan confocal and functional OCT systems may provide a feasible solution to pursue functional IOS mapping of human photoreceptors. Some interesting IOSs have already been detected in inner retinal layers, but better development of the IOS instruments and software algorithms is required to achieve optimal physiological assessment of inner retinal neurons.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
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Xincheng Yao and Benquan Wang "Intrinsic optical signal imaging of retinal physiology: a review," Journal of Biomedical Optics 20(9), 090901 (25 September 2015). https://doi.org/10.1117/1.JBO.20.9.090901
Published: 25 September 2015
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Cited by 41 scholarly publications.
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KEYWORDS
Information operations
Retina
Optical coherence tomography
Physiology
Confocal microscopy
Rods
Intrinsic optical signal imaging
CHORUS Article. This article was made freely available starting 24 September 2016
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