10 September 2015 Monitoring the progression from intraductal carcinoma to invasive ductal carcinoma based on multiphoton microscopy
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Abstract
Intraductal carcinoma is a precancerous lesion of the breast and the immediate precursor of invasive ductal carcinoma. Multiphoton microscopy (MPM) was used to monitor the progression from intraductal carcinoma to invasive ductal carcinoma, which can improve early detection of precursor lesions and halt progression to invasive neoplastic disease. It was found that MPM has the capability to reveal the qualitative changes in features of cells, structure of basement membranes, and architecture of collagens during the development from intraductal carcinoma to invasive ductal carcinoma, as well as the quantitative alterations in nuclear area, circle length of basement membrane, and collagen density. Combined with intra-fiberoptic ductoscopy or transdermal biopsy needle, MPM has the potential to provide immediate histological diagnosis of tumor progression in the field of breast carcinoma.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yan Wu, Fangmeng Fu, Yuane Lian, Yuting Nie, Shuangmu Zhuo, Chuan Wang, Jianxin Chen, "Monitoring the progression from intraductal carcinoma to invasive ductal carcinoma based on multiphoton microscopy," Journal of Biomedical Optics 20(9), 096007 (10 September 2015). https://doi.org/10.1117/1.JBO.20.9.096007 . Submission:
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