27 January 2016 Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer’s disease
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Abstract
The terahertz (THz) absorption and index of refraction of brain tissues from a mouse model of Alzheimer’s disease (AD) and a control wild-type (normal) mouse were compared using THz time-domain spectroscopy (THz-TDS). Three dominating absorption peaks associated to torsional–vibrational modes were observed in AD tissue, at about 1.44, 1.8, and 2.114 THz, closer to the peaks of free tryptophan molecules than in normal tissue. A possible reason is that there is more free tryptophan in AD brain tissue, while in normal brain tissue more tryptophan is attached to other molecules. Our study suggests that THz-absorption modes may be used as an AD biomarker fingerprint in brain, and that THz-TDS is a promising technique for early diagnosis of AD.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Lingyan Shi, Lingyan Shi, Pavel Shumyatsky, Pavel Shumyatsky, Adrián Rodríguez-Contreras, Adrián Rodríguez-Contreras, Robert R. Alfano, Robert R. Alfano, } "Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer’s disease," Journal of Biomedical Optics 21(1), 015014 (27 January 2016). https://doi.org/10.1117/1.JBO.21.1.015014 . Submission:
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