18 January 2016 Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study
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Abstract
We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of ∼1  μm, OCT imaging delineates BCC depth spreading (margins) with resolution of ∼7  μm. When delineating margins in 20 specimens of superficial and nodular BCCs, depth could be reliably determined down to ∼600  μm, and agreement with histology was within about ±50  μm.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Nicusor V. Iftimia, Nicusor V. Iftimia, Gary Peterson, Gary Peterson, Ernest W. Chang, Ernest W. Chang, Gopi N. Maguluri, Gopi N. Maguluri, William J. Fox, William J. Fox, Milind Rajadhyaksha, Milind Rajadhyaksha, } "Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study," Journal of Biomedical Optics 21(1), 016006 (18 January 2016). https://doi.org/10.1117/1.JBO.21.1.016006 . Submission:
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