20 January 2016 Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging
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J. of Biomedical Optics, 21(1), 016009 (2016). doi:10.1117/1.JBO.21.1.016009
We present experimental results that validate our imaging technique termed photomagnetic imaging (PMI). PMI illuminates the medium under investigation with a near-infrared light and measures the induced temperature increase using magnetic resonance imaging. A multiphysics solver combining light and heat propagation is used to model spatiotemporal distribution of temperature increase. Furthermore, a dedicated PMI reconstruction algorithm has been developed to reveal high-resolution optical absorption maps from temperature measurements. Being able to perform measurements at any point within the medium, PMI overcomes the limitations of conventional diffuse optical imaging. We present experimental results obtained on agarose phantoms mimicking biological tissue with inclusions having either different sizes or absorption contrasts, located at various depths. The reconstructed images show that PMI can successfully resolve these inclusions with high resolution and recover their absorption coefficient with high-quantitative accuracy. Even a 1-mm inclusion located 6-mm deep is recovered successfully and its absorption coefficient is underestimated by only 32%. The improved PMI system presented here successfully operates under the maximum skin exposure limits defined by the American National Standards Institute, which opens up the exciting possibility of its future clinical use for diagnostic purposes.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Farouk Nouizi, Alex T. Luk, Dave Thayer, Yuting Lin, Seunghoon Ha, Gultekin Gulsen, "Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging," Journal of Biomedical Optics 21(1), 016009 (20 January 2016). https://doi.org/10.1117/1.JBO.21.1.016009

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