7 January 2016 Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection
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Abstract
Photodynamic antimicrobial chemotherapy (PACT) is an effective method for killing bacterial cells in view of the increasing problem of multiantibiotic resistance. We herein reported the PACT effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine β-carbonylphthalocyanine zinc (ZnPc-(Lys)5). Compared with its anionic ZnPc counterpart, ZnPc-(Lys)5 showed an enhanced antibacterial efficacy in vitro and in an animal model of localized infection. Meanwhile, ZnPc-(Lys)5 was observed to significantly reduce the wound skin blood flow during wound healing, indicating an anti-inflammation activity. This study provides new insight on the mechanisms of PACT in bacterial skin infection.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Zhuo Chen, Zhuo Chen, Yaxin Zhang, Yaxin Zhang, Dong Wang, Dong Wang, Linsen Li, Linsen Li, Shanyong Zhou, Shanyong Zhou, Joy H. Huang, Joy H. Huang, Jincan Chen, Jincan Chen, Ping Hu, Ping Hu, Mingdong Huang, Mingdong Huang, } "Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection," Journal of Biomedical Optics 21(1), 018001 (7 January 2016). https://doi.org/10.1117/1.JBO.21.1.018001 . Submission:
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