Optical oximetry of volume-oscillating vascular compartments: contributions from oscillatory blood flow

Jana Marie Kainerstorfer; Angelo Sassaroli; Sergio Fantini

doi:10.1117/1.JBO.21.10.101408

1 March 2016 Optical oximetry of volume-oscillating vascular compartments: contributions from oscillatory blood flow

Jana Marie Kainerstorfer, Angelo Sassaroli, Sergio Fantini

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Journal of Biomedical Optics, Vol. 21, Issue 10, 101408 (March 2016). https://doi.org/10.1117/1.JBO.21.10.101408

Abstract

We present a quantitative analysis of dynamic diffuse optical measurements to obtain oxygen saturation of hemoglobin in volume oscillating compartments. We used a phasor representation of oscillatory hemodynamics at the heart rate and respiration frequency to separate the oscillations of tissue concentrations of oxyhemoglobin (O) and deoxyhemoglobin (D) into components due to blood volume (subscript V) and blood flow (subscript F): O=O_V+O_F, D=D_V+D_F. This is achieved by setting the phase angle Arg(O_F)−Arg(O), which can be estimated by a hemodynamic model that we recently developed. We found this angle to be −72 deg for the cardiac pulsation at 1 Hz, and −7 deg for paced breathing at 0.1 Hz. Setting this angle, we can obtain the oxygen saturation of hemoglobin of the volume-oscillating vascular compartment, S_V=|O_V|/(|O_V|+|D_V|). We demonstrate this approach with cerebral near-infrared spectroscopy measurements on healthy volunteers at rest (n=4) and during 0.1 Hz paced breathing (n=3) with a 24-channel system. Rest data at the cardiac frequency were used to calculate the arterial saturation, S⁽^a⁾; over all subjects and channels, we found 〈S_V〉=^〈S⁽^a⁾〉=0.96±0.02. In the case of paced breathing, we found 〈S_V〉=0.66±0.14, which reflects venous-dominated hemodynamics at the respiratory frequency.

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Jana Marie Kainerstorfer, Angelo Sassaroli, and Sergio Fantini "Optical oximetry of volume-oscillating vascular compartments: contributions from oscillatory blood flow," Journal of Biomedical Optics 21(10), 101408 (1 March 2016). https://doi.org/10.1117/1.JBO.21.10.101408

Published: 1 March 2016

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