Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain

Kristen T. Tgavalekos; Jana M. Kainerstorfer; Angelo Sassaroli; Sergio Fantini

doi:10.1117/1.JBO.21.10.101410

28 March 2016 Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain

Kristen T. Tgavalekos, Jana M. Kainerstorfer, Angelo Sassaroli, Sergio Fantini

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Journal of Biomedical Optics, Vol. 21, Issue 10, 101410 (March 2016). https://doi.org/10.1117/1.JBO.21.10.101410

Abstract

We present a near-infrared spectroscopy (NIRS) study of local hemodynamics in the breast and the brain (prefrontal cortex) of healthy volunteers in a protocol involving periodic perturbations to the systemic arterial blood pressure. These periodic perturbations were achieved by cyclic inflation (to a pressure of 200 mmHg) and deflation (at frequencies of 0.046, 0.056, 0.063, 0.071, and 0.083 Hz) of two pneumatic cuffs wrapped around the subject’s thighs. As a result of these systemic perturbations, the concentrations of deoxy- and oxyhemoglobin in tissue (D and O, respectively) oscillate at the set frequency. We found that the oscillations of D and O in breast tissue are in-phase at all frequencies considered, a result that we attribute to dominant contributions from blood volume oscillations. In contrast, D and O oscillations in brain tissue feature a frequency-dependent phase difference, which we attribute to significant contributions from cerebral blood flow oscillations. Frequency-resolved measurements of D and O oscillations are exploited by the technique of coherent hemodynamics spectroscopy for the assessment of cerebrovascular parameters and cerebral autoregulation. We show the relevant physiological information content of NIRS measurements of oscillatory hemodynamics, which have qualitatively distinct features in the healthy breast and healthy brain.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Kristen T. Tgavalekos, Jana M. Kainerstorfer, Angelo Sassaroli, and Sergio Fantini "Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain," Journal of Biomedical Optics 21(10), 101410 (28 March 2016). https://doi.org/10.1117/1.JBO.21.10.101410

Published: 28 March 2016

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