10 November 2016 Separating melanin from hemodynamics in nevi using multimode hyperspectral dermoscopy and spatial frequency domain spectroscopy
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Abstract
Changes in the pattern and distribution of both melanocytes (pigment producing) and vasculature (hemoglobin containing) are important in distinguishing melanocytic proliferations. The ability to accurately measure melanin distribution at different depths and to distinguish it from hemoglobin is clearly important when assessing pigmented lesions (benign versus malignant). We have developed a multimode hyperspectral dermoscope (SkinSpect™) able to more accurately image both melanin and hemoglobin distribution in skin. SkinSpect uses both hyperspectral and polarization-sensitive measurements. SkinSpect’s higher accuracy has been obtained by correcting for the effect of melanin absorption on hemoglobin absorption in measurements of melanocytic nevi. In vivo human skin pigmented nevi (N=20) were evaluated with the SkinSpect, and measured melanin and hemoglobin concentrations were compared with spatial frequency domain spectroscopy (SFDS) measurements. We confirm that both systems show low correlation of hemoglobin concentrations with regions containing different melanin concentrations (R=0.13 for SFDS, R=0.07 for SkinSpect).
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Fartash Vasefi, Fartash Vasefi, Nicholas MacKinnon, Nicholas MacKinnon, Rolf Saager, Rolf Saager, Kristen M. Kelly, Kristen M. Kelly, Tyler Maly, Tyler Maly, Nicholas Booth, Nicholas Booth, Anthony J. Durkin, Anthony J. Durkin, Daniel L. Farkas, Daniel L. Farkas, } "Separating melanin from hemodynamics in nevi using multimode hyperspectral dermoscopy and spatial frequency domain spectroscopy," Journal of Biomedical Optics 21(11), 114001 (10 November 2016). https://doi.org/10.1117/1.JBO.21.11.114001 . Submission:
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