Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images

Yasufumi Asao; Yohei Hashizume; Takahiro Suita; Ken-ichi Nagae; Kazuhiko Fukutani; Yoshiaki Sudo; Toshikazu Matsushita; Shuichi Kobayashi; Mariko Tokiwa; Iku Yamaga; Elham Fakhrejahani; Masae Torii; Masahiro Kawashima; Masahiro Takada; Shotaro Kanao; Masako Kataoka; Tsuyoshi Shiina; Masakazu Toi

doi:10.1117/1.JBO.21.11.116009

23 November 2016 Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images

Yasufumi Asao, Yohei Hashizume, Takahiro Suita, Ken-ichi Nagae, Kazuhiko Fukutani, Yoshiaki Sudo, Toshikazu Matsushita, Shuichi Kobayashi, Mariko Tokiwa, Iku Yamaga, Elham Fakhrejahani, Masae Torii, Masahiro Kawashima, Masahiro Takada, Shotaro Kanao, Masako Kataoka, Tsuyoshi Shiina, Masakazu Toi

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Journal of Biomedical Optics, Vol. 21, Issue 11, 116009 (November 2016). https://doi.org/10.1117/1.JBO.21.11.116009

Abstract

We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast using the scanning module of a US transducer, a PA detector, and optical prisms. The resolution of the PA images exhibits improvement from 2 to 1 mm compared to images acquired using our previous prototype. The maximum scan area of PAM-02 is 90 mm along the horizontal axis and 150 mm along the vertical axis. In a phantom experiment, the available depth was at least 45 mm. A representative example of the application of the PAM-02 prototype in clinical research at Kyoto University is presented and shows S-factor images, which are considered an approximation parameter related to hemoglobin saturation of tumor-related blood vessels. We confirmed the applicability of the system for anatomical and biological research.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Yasufumi Asao, Yohei Hashizume, Takahiro Suita, Ken-ichi Nagae, Kazuhiko Fukutani, Yoshiaki Sudo, Toshikazu Matsushita, Shuichi Kobayashi, Mariko Tokiwa, Iku Yamaga, Elham Fakhrejahani, Masae Torii, Masahiro Kawashima, Masahiro Takada, Shotaro Kanao, Masako Kataoka, Tsuyoshi Shiina, and Masakazu Toi "Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images," Journal of Biomedical Optics 21(11), 116009 (23 November 2016). https://doi.org/10.1117/1.JBO.21.11.116009

Published: 23 November 2016

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