28 October 2016 Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography
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Abstract
We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of penetration depth and imaging quality. OCA reduces optical inhomogeneity of a highly scattering sample, and the wavefront shaping of illumination light controls multiple scattering, resulting in an enhancement of the penetration depth and signal-to-noise ratio. A tissue phantom study shows that concurrent applications of OCA and wavefront shaping successfully operate in OCT imaging. The penetration depth enhancement is further demonstrated for
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Hyeonseung Yu, Hyeonseung Yu, Peter Lee, Peter Lee, YoungJu Jo, YoungJu Jo, KyeoReh Lee, KyeoReh Lee, Valery V. Tuchin, Valery V. Tuchin, Yong Jeong, Yong Jeong, YongKeun Park, YongKeun Park, } "Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography," Journal of Biomedical Optics 21(12), 121510 (28 October 2016). https://doi.org/10.1117/1.JBO.21.12.121510 . Submission:
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