1 December 2016 Noninvasive in vivo multispectral optoacoustic imaging of apoptosis in triple negative breast cancer using indocyanine green conjugated phosphatidylserine monoclonal antibody
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Abstract
Noninvasive and nonradioactive imaging modality to track and image apoptosis during chemotherapy of triple negative breast cancer is much needed for an effective treatment plan. Phosphatidylserine (PS) is a biomarker transiently exposed on the outer surface of the cells during apoptosis. Its externalization occurs within a few hours of an apoptotic stimulus by a chemotherapy drug and leads to presentation of millions of phospholipid molecules per apoptotic cell on the cell surface. This makes PS an abundant and accessible target for apoptosis imaging. In the current work, we show that PS monoclonal antibody tagged with indocyanine green (ICG) can help to track and image apoptosis using multispectral optoacoustic tomography
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Ravi Kumar Kannadorai, Ravi Kumar Kannadorai, Sunil Kumar Udumala, Sunil Kumar Udumala, Sidney Yu Wing Kwok, Sidney Yu Wing Kwok, } "Noninvasive in vivo multispectral optoacoustic imaging of apoptosis in triple negative breast cancer using indocyanine green conjugated phosphatidylserine monoclonal antibody," Journal of Biomedical Optics 21(12), 126002 (1 December 2016). https://doi.org/10.1117/1.JBO.21.12.126002 . Submission:
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