20 May 2016 Ex vivo laser lipolysis assisted with radially diffusing optical applicator
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Abstract
Laser-assisted lipolysis has been implemented to reduce body fat in light of thermal interactions with adipose tissue. However, using a flat fiber with high irradiance often needs rapid cannula movements and even undesirable thermal injury due to direct tissue contact. The aim of the current study was to explore the feasibility of a radially diffusing optical applicator to liquefy the adipose tissue for effective laser lipolysis. The proposed diffuser was evaluated with a flat fiber in terms of temperature elevation and tissue liquefaction after laser lipolysis with a 980-nm wavelength. Given the same power (20 W), the diffusing applicator generated a 30% slower temperature increase with a 25% lower maximum temperature (84±3.2°C in 1 min; p<0.001) in the tissue, compared with the flat fiber. Under the equivalent temperature development, the diffuser induced up to fivefold larger area of the adipose liquefaction due to radial light emission than the flat fiber. Ex vivo tissue tests for 5-min irradiation demonstrated that the diffuser (1.24±0.15  g) liquefied 66% more adipose tissue than the flat fiber (0.75±0.05  g). The proposed diffusing applicator can be a feasible therapeutic device for laser lipolysis due to low temperature development and wide coverage of thermal treatment.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Jieun Hwang, Nguyen Trung Hau, Sung Yeon Park, Yun-Hee Rhee, Jin-Chul Ahn, Hyun Wook Kang, "Ex vivo laser lipolysis assisted with radially diffusing optical applicator," Journal of Biomedical Optics 21(5), 058001 (20 May 2016). https://doi.org/10.1117/1.JBO.21.5.058001
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