17 December 2015 In vivo photoacoustic tomography of myoglobin oxygen saturation
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Abstract
Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO2-Mb). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO2-Mb change in the backbone muscle in vivo.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Li Lin, Junjie Yao, Lei Li, Lihong V. Wang, "In vivo photoacoustic tomography of myoglobin oxygen saturation," Journal of Biomedical Optics 21(6), 061002 (17 December 2015). https://doi.org/10.1117/1.JBO.21.6.061002 . Submission:
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