17 December 2015 In vivo photoacoustic tomography of myoglobin oxygen saturation
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Abstract
Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO2-Mb). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO2-Mb change in the backbone muscle in vivo.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Li Lin, Li Lin, Junjie Yao, Junjie Yao, Lei Li, Lei Li, Lihong V. Wang, Lihong V. Wang, } "In vivo photoacoustic tomography of myoglobin oxygen saturation," Journal of Biomedical Optics 21(6), 061002 (17 December 2015). https://doi.org/10.1117/1.JBO.21.6.061002 . Submission:
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