15 June 2016 Dual-band optical coherence tomography using a single supercontinuum laser source
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J. of Biomedical Optics, 21(6), 066013 (2016). doi:10.1117/1.JBO.21.6.066013
Abstract
We developed a simultaneous visible-light (Vis) and near-infrared (NIR) dual-band optical coherence tomography (OCT) system using a single supercontinuum laser source. The goal was to benchmark our newly developed Vis-OCT against the well-developed NIR-OCT. The Vis-OCT subsystem operated at 91 nm full-width-at-half-maximum (FWHM) bandwidth centered at 566 nm; the NIR-OCT subsystem operated at 93 nm FWHM bandwidth centered at 841 nm. The axial resolutions were 1.8 and 4.4  μm in air for the Vis- and NIR-OCT subsystems, respectively. We compared the respective performances, including anatomical imaging, angiography, absolute retinal blood flow measurements, and spectroscopic analysis for retinal blood oxygen saturation (sO2), between the two subsystems in rodents in vivo. While demonstrating minor discrepancies related to operation wavelengths, both subsystems showed comparable performances in the first three tests. However, we were only able to retrieve sO2 using the Vis-OCT subsystem.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Siyu Chen, Xiao Shu, Ji Yi, Amani A. Fawzi, Hao F. Zhang, "Dual-band optical coherence tomography using a single supercontinuum laser source," Journal of Biomedical Optics 21(6), 066013 (15 June 2016). http://dx.doi.org/10.1117/1.JBO.21.6.066013
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KEYWORDS
Optical coherence tomography

Near infrared

Retina

Blood

Blood circulation

Angiography

Visible radiation

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