29 July 2016 Hemodynamic changes in a rat parietal cortex after endothelin-1-induced middle cerebral artery occlusion monitored by optical coherence tomography
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Abstract
A blockage of the middle cerebral artery (MCA) on the cortical branch will seriously affect the blood supply of the cerebral cortex. Real-time monitoring of MCA hemodynamic parameters is critical for therapy and rehabilitation. Optical coherence tomography (OCT) is a powerful imaging modality that can produce not only structural images but also functional information on the tissue. We use OCT to detect hemodynamic changes after MCA branch occlusion. We injected a selected dose of endothelin-1 (ET-1) at a depth of 1 mm near the MCA and let the blood vessels follow a process first of occlusion and then of slow reperfusion as realistically as possible to simulate local cerebral ischemia. During this period, we used optical microangiography and Doppler OCT to obtain multiple hemodynamic MCA parameters. The change trend of these parameters from before to after ET-1 injection clearly reflects the dynamic regularity of the MCA. These results show the mechanism of the cerebral ischemia-reperfusion process after a transient middle cerebral artery occlusion and confirm that OCT can be used to monitor hemodynamic parameters.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Jian Liu, Jian Liu, Yushu Ma, Yushu Ma, Shidan Dou, Shidan Dou, Yi Wang, Yi Wang, Dongsheng La, Dongsheng La, Jianghong Liu, Jianghong Liu, Zhenhe Ma, Zhenhe Ma, } "Hemodynamic changes in a rat parietal cortex after endothelin-1-induced middle cerebral artery occlusion monitored by optical coherence tomography," Journal of Biomedical Optics 21(7), 075014 (29 July 2016). https://doi.org/10.1117/1.JBO.21.7.075014 . Submission:
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