12 July 2016 Continuous-terahertz-wave molecular imaging system for biomedical applications
Author Affiliations +
J. of Biomedical Optics, 21(7), 076006 (2016). doi:10.1117/1.JBO.21.7.076006
Molecular imaging techniques are becoming increasingly important in biomedical research and potentially in clinical practice. We present a continuous-terahertz (THz)-wave molecular imaging system for biomedical applications, in which an infrared (IR) laser is integrated into a 0.2-THz reflection-mode continuous-THz-wave imaging system to induce surface plasmon polaritons on the nanoparticles and further improve the intensity of the reflected signal from the water around the nanoparticles. A strong and rapid increment of the reflected THz signal in the nanoparticle solution upon the IR laser irradiation is demonstrated, using either gold or silver nanoparticles. This low-cost, simple, and stable continuous-THz-wave molecular imaging system is suitable for miniaturization and practical imaging applications; in particular, it shows great promise for cancer diagnosis and nanoparticle drug-delivery monitoring.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Rui Zhang, Liangliang Zhang, Tong Wu, Ruixue Wang, Shasha Zuo, Dong Wu, Cunlin Zhang, Jue Zhang, Jing Fang, "Continuous-terahertz-wave molecular imaging system for biomedical applications," Journal of Biomedical Optics 21(7), 076006 (12 July 2016). https://doi.org/10.1117/1.JBO.21.7.076006

Imaging systems

Terahertz radiation

Infrared lasers


Molecular imaging


Biomedical optics

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