8 August 2016 Low-cost compact diffuse speckle contrast flowmeter using small laser diode and bare charge-coupled-device
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We report a low-cost compact diffuse speckle contrast flowmeter (DSCF) consisting of a small laser diode and a bare charge-coupled-device (CCD) chip, which can be used for contact measurements of blood flow variations in relatively deep tissues (up to ∼8  mm). Measurements of large flow variations by the contact DSCF probe are compared to a noncontact CCD-based diffuse speckle contrast spectroscopy and a standard contact diffuse correlation spectroscopy in tissue phantoms and a human forearm. Bland–Altman analysis shows no significant bias with good limits of agreement among these measurements: 96.5%±2.2% (94.4% to 100.0%) in phantom experiments and 92.8% in the forearm test. The relatively lower limit of agreement observed in the in vivo measurements (92.8%) is likely due to heterogeneous reactive responses of blood flow in different regions/volumes of the forearm tissues measured by different probes. The low-cost compact DSCF device holds great potential to be broadly used for continuous and longitudinal monitoring of blood flow alterations in ischemic/hypoxic tissues, which are usually associated with various vascular diseases.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Chong Huang, Chong Huang, Myeongsu Seong, Myeongsu Seong, Joshua Paul Morgan, Joshua Paul Morgan, Siavash Mazdeyasna, Siavash Mazdeyasna, Jae Gwan Kim, Jae Gwan Kim, Jeffrey Todd Hastings, Jeffrey Todd Hastings, Guoqiang Yu, Guoqiang Yu, } "Low-cost compact diffuse speckle contrast flowmeter using small laser diode and bare charge-coupled-device," Journal of Biomedical Optics 21(8), 080501 (8 August 2016). https://doi.org/10.1117/1.JBO.21.8.080501 . Submission:

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