31 May 2016 Study of optical clearing in polarization measurements by Monte Carlo simulations with anisotropic tissue-mimicking models
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Abstract
We conducted Monte Carlo simulations based on anisotropic sclera-mimicking models to examine the polarization features in Mueller matrix polar decomposition (MMPD) parameters during the refractive index matching process, which is one of the major mechanisms of optical clearing. In a preliminary attempt, by changing the parameters of the models, wavelengths, and detection geometries, we demonstrate how the depolarization coefficient and retardance vary during the refractive index matching process and explain the polarization features using the average value and standard deviation of scattering numbers of the detected photons. We also study the depth-resolved polarization features during the gradual progression of the refractive index matching process. The results above indicate that the refractive index matching process increases the depth of polarization measurements and may lead to higher contrast between tissues of different anisotropies in deeper layers. MMPD-derived polarization parameters can characterize the refractive index matching process qualitatively.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Dongsheng Chen, Dongsheng Chen, Nan Zeng, Nan Zeng, Yunfei Wang, Yunfei Wang, Honghui He, Honghui He, Valery V. Tuchin, Valery V. Tuchin, Hui Ma, Hui Ma, } "Study of optical clearing in polarization measurements by Monte Carlo simulations with anisotropic tissue-mimicking models," Journal of Biomedical Optics 21(8), 081209 (31 May 2016). https://doi.org/10.1117/1.JBO.21.8.081209 . Submission:
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