23 August 2016 Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules
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Abstract
The controlled release of encapsulated molecules from a microcapsule is a promising method of targeted drug delivery. Laser-triggered methods for the release of encapsulated molecules have the advantage of spatial and temporal controllability. In this study, we demonstrated the release of encapsulated molecules from biodegradable polymer-based microcapsules using near-infrared femtosecond laser pulses. The polylactic-co-glycolic acid microcapsules encapsulating fluorescein isothiocyanate-dextran molecules were fabricated using a dual-coaxial nozzle system. Irradiation of femtosecond laser pulses enhanced the release of the molecules from the microcapsules, which was accompanied by a decrease in the residual ratio of the microcapsules. The laser-induced modification of the surface of the shell of the microcapsules indicated the potential for sustained release as well as burst release.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Kazumasa Ariyasu, Atsuhiro Ishii, Taiga Umemoto, Mitsuhiro Terakawa, "Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules," Journal of Biomedical Optics 21(8), 085003 (23 August 2016). https://doi.org/10.1117/1.JBO.21.8.085003 . Submission:
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