18 August 2016 Aptamer-based fiber sensor for thrombin detection
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Abstract
The detection of thrombin based on aptamer binding is studied using two different optical fiber-based configurations: long period gratings coated with a thin layer of titanium dioxide and surface plasmon resonance devices in optical fibers coated with a multilayer of gold and titanium dioxide. These structures are functionalized and the performance to detect thrombin in the range 10 to 100 nM is compared in transmission mode. The sensitivity to the surrounding refractive index (RI) of the plasmonic device is higher than 3100  nm RIU−1 in the RI range 1.335 to 1.355, a factor of 20 greater than the sensitivity of the coated grating. The detection of 10 nM of thrombin was accomplished with a wavelength shift of 3.5 nm and a resolution of 0.54 nM.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Luís Coelho, José Manuel Marques Martins de Almeida, José Luís Santos, Pedro Alberto da Silva Jorge, Maria Cristina L. Martins, Diana Viegas, Raquel B. Queirós, "Aptamer-based fiber sensor for thrombin detection," Journal of Biomedical Optics 21(8), 087005 (18 August 2016). https://doi.org/10.1117/1.JBO.21.8.087005 . Submission:
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