14 September 2016 Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization
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Abstract
Ocular angiogenesis is a blinding complication of age-related macular degeneration and other retinal vascular diseases. Clinical imaging approaches to detect inflammation prior to the onset of neovascularization in these diseases may enable early detection and timely therapeutic intervention. We demonstrate the feasibility of a previously developed cyclooxygenase-2 (COX-2) targeted molecular imaging probe, fluorocoxib A, for imaging retinal inflammation in a mouse model of laser-induced choroidal neovascularization. This imaging probe exhibited focal accumulation within laser-induced neovascular lesions, with minimal detection in proximal healthy tissue. The selectivity of the probe for COX-2 was validated
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Md. Jashim Uddin, Md. Jashim Uddin, Chauca E. Moore, Chauca E. Moore, Brenda C. Crews, Brenda C. Crews, Cristina K. Daniel, Cristina K. Daniel, Kebreab Ghebreselasie, Kebreab Ghebreselasie, J. Oliver McIntyre, J. Oliver McIntyre, Lawrence J. Marnett, Lawrence J. Marnett, Ashwath Jayagopal, Ashwath Jayagopal, } "Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization," Journal of Biomedical Optics 21(9), 090503 (14 September 2016). https://doi.org/10.1117/1.JBO.21.9.090503 . Submission:
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