22 May 2017 Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture
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J. of Biomedical Optics, 22(5), 050501 (2017). doi:10.1117/1.JBO.22.5.050501
Abstract
To detect small-scale changes in tissue with optical techniques, small sampling volumes and, therefore, short source–detector separations are required. In this case, reflectance measurements are not adequately described by the diffusion approximation. Previous studies related subdiffusive reflectance to γ or σ , which parameterize the phase function. Recently, it was demonstrated that σ predicts subdiffusive reflectance better than γ , and that σ becomes less predictive for lower numerical apertures (NAs). We derive and evaluate the parameter R p NA , which incorporates the NA of the detector and the integral of the phase function over the NA in the backward and forward directions. Monte Carlo simulations are performed for overlapping source/detector geometries for a range of phase functions, reduced scattering coefficients, NAs, and source/detector diameters. R p NA improves prediction of the measured reflectance compared to γ and σ . It is, therefore, expected that R p NA will improve derivation of optical properties from subdiffusive measurements.
Anouk L. Post, Steven L. Jacques, Henricus J. C. M. Sterenborg, Dirk J. Faber, Ton G. van Leeuwen, "Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture," Journal of Biomedical Optics 22(5), 050501 (22 May 2017). http://dx.doi.org/10.1117/1.JBO.22.5.050501
Submission: Received 14 February 2017; Accepted 1 May 2017
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KEYWORDS
Reflectivity

Sensors

Scattering

Tissue optics

Photons

Light scattering

Monte Carlo methods

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