Optical coherence tomography-based topography determination of corneal grafts in eye bank cultivation

Angela Damian; Berthold Seitz; Achim Langenbucher; Timo Eppig

doi:10.1117/1.JBO.22.1.016001

2 January 2017 Optical coherence tomography-based topography determination of corneal grafts in eye bank cultivation

Angela Damian, Berthold Seitz, Achim Langenbucher, Timo Eppig

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Journal of Biomedical Optics, Vol. 22, Issue 1, 016001 (January 2017). https://doi.org/10.1117/1.JBO.22.1.016001

Abstract

Vision loss due to corneal injuries or diseases can be treated by transplantation of human corneal grafts (keratoplasty). However, quality assurance in retrieving and cultivating the tissue transplants is confined to visual and microbiological testing. To identify previous refractive surgery or morphological alterations, an automatic, noncontact, sterile screening procedure is required. Twenty-three corneal grafts have been measured in organ culture with a clinical spectral-domain optical coherence tomographer. Employing a biconic surface fit with 10 degrees of freedom, the radii of curvature and conic constants could be estimated for the anterior and posterior corneal surfaces. Thereupon, central corneal thickness, refractive values, and astigmatism have been calculated. Clinical investigations are required to elaborate specific donor–host matching in the future.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Angela Damian, Berthold Seitz, Achim Langenbucher, and Timo Eppig "Optical coherence tomography-based topography determination of corneal grafts in eye bank cultivation," Journal of Biomedical Optics 22(1), 016001 (2 January 2017). https://doi.org/10.1117/1.JBO.22.1.016001

Received: 1 September 2016; Accepted: 5 December 2016; Published: 2 January 2017

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