13 January 2017 Design of a portable imager for near-infrared visualization of cutaneous wounds
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A portable imager developed for real-time imaging of cutaneous wounds in research settings is described. The imager consists of a high-resolution near-infrared CCD camera capable of detecting both bioluminescence and fluorescence illuminated by an LED ring with a rotatable filter wheel. All external components are integrated into a compact camera attachment. The device is demonstrated to have competitive performance with a commercial animal imaging enclosure box setup in beam uniformity and sensitivity. Specifically, the device was used to visualize the bioluminescence associated with increased reactive oxygen species activity during the wound healing process in a cutaneous wound inflammation model. In addition, this device was employed to observe the fluorescence associated with the activity of matrix metalloproteinases in a mouse lipopolysaccharide-induced infection model. Our results support the use of the portable imager design as a noninvasive and real-time imaging tool to assess the extent of wound inflammation and infection.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Zhaoqiang Peng, Zhaoqiang Peng, Jun Zhou, Jun Zhou, Ashley Dacy, Ashley Dacy, Deyin Zhao, Deyin Zhao, Vasant Kearney, Vasant Kearney, Weidong Zhou, Weidong Zhou, Liping Tang, Liping Tang, Wenjing Hu, Wenjing Hu, } "Design of a portable imager for near-infrared visualization of cutaneous wounds," Journal of Biomedical Optics 22(1), 016010 (13 January 2017). https://doi.org/10.1117/1.JBO.22.1.016010 . Submission: Received: 6 July 2016; Accepted: 27 December 2016
Received: 6 July 2016; Accepted: 27 December 2016; Published: 13 January 2017

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