13 October 2017 Toward jet injection by continuous-wave laser cavitation
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This is a study motivated by the need to develop a needle-free device for eliminating major global healthcare problems caused by needles. The generation of liquid jets by means of a continuous-wave laser, focused into a light absorbing solution, was studied with the aim of developing a portable and affordable jet injector. We designed and fabricated glass microfluidic devices, which consist of a chamber where thermocavitation is created and a tapered channel. The growth of a vapor bubble displaces and expels the liquid through the channel as a fast traveling jet. Different parameters were varied with the purpose of increasing the jet velocity. The velocity increases with smaller channel diameters and taper ratios, whereas larger chambers significantly reduce the jet speed. It was found that the initial position of the liquid–air meniscus interface and its dynamics contribute to increased jet velocities. A maximum velocity of 94 ± 3    m / s for a channel diameter of D = 120    μ m , taper ratio n = 0.25 , and chamber length E = 200    μ m was achieved. Finally, agarose gel-based skin phantoms were used to demonstrate the potential of our devices to penetrate the skin. The maximum penetration depth achieved was 1    mm , which is sufficient to penetrate the stratum corneum and for most medical applications. A meta-analysis shows that larger injection volumes will be required as a next step to medical relevance for laser-induced jet injection techniques in general.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Carla Berrospe Rodríguez, Carla Berrospe Rodríguez, Claas Willem Visser, Claas Willem Visser, Stefan Schlautmann, Stefan Schlautmann, David Fernandez Rivas, David Fernandez Rivas, Rubén Ramos-García, Rubén Ramos-García, } "Toward jet injection by continuous-wave laser cavitation," Journal of Biomedical Optics 22(10), 105003 (13 October 2017). https://doi.org/10.1117/1.JBO.22.10.105003 . Submission: Received: 10 July 2017; Accepted: 15 September 2017
Received: 10 July 2017; Accepted: 15 September 2017; Published: 13 October 2017

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