27 October 2017 Optical properties of the human round window membrane
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Abstract
Optical techniques are effective tools for diagnostic applications in medicine and are particularly attractive for the noninvasive analysis of biological tissues and fluids in vivo. Noninvasive examinations of substances via a fiber optic probe need to consider the optical properties of biological tissues obstructing the optical path. This applies to the analysis of the human perilymph, which is located behind the round window membrane. The composition of this inner ear liquid is directly correlated to inner ear hearing loss. In this work, experimental methods for studying the optical properties of the human round window membrane ex vivo are presented. For the first time, a comprehensive investigation of this tissue is performed, including optical transmission, forward scattering, and Raman scattering. The results obtained suggest the application of visible wavelengths ( > 400    nm ) for investigating the perilymph behind the round window membrane in future.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Martin Höhl, Martin Höhl, Daphne DeTemple, Daphne DeTemple, Stefan Lyutenski, Stefan Lyutenski, Georg Leuteritz, Georg Leuteritz, Arthur Varkentin, Arthur Varkentin, Heike Andrea Schmitt, Heike Andrea Schmitt, Thomas Lenarz, Thomas Lenarz, Bernhard Roth, Bernhard Roth, Merve Meinhardt-Wollweber, Merve Meinhardt-Wollweber, Uwe Morgner, Uwe Morgner, } "Optical properties of the human round window membrane," Journal of Biomedical Optics 22(10), 105007 (27 October 2017). https://doi.org/10.1117/1.JBO.22.10.105007 . Submission: Received: 5 May 2017; Accepted: 26 September 2017
Received: 5 May 2017; Accepted: 26 September 2017; Published: 27 October 2017
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