11 October 2017 Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration
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J. of Biomedical Optics, 22(10), 106002 (2017). doi:10.1117/1.JBO.22.10.106002
Abstract
Transbronchial needle aspiration (TBNA) of small lesions or lymph nodes in the lung may result in nondiagnostic tissue samples. We demonstrate the integration of an optical coherence tomography (OCT) probe into a 19-gauge flexible needle for lung tissue aspiration. This probe allows simultaneous visualization and aspiration of the tissue. By eliminating the need for insertion and withdrawal of a separate imaging probe, this integrated design minimizes the risk of dislodging the needle from the lesion prior to aspiration and may facilitate more accurate placement of the needle. Results from in situ imaging in a sheep lung show clear distinction between solid tissue and two typical constituents of nondiagnostic samples (adipose and lung parenchyma). Clinical translation of this OCT-guided aspiration needle holds promise for improving the diagnostic yield of TBNA.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Jiawen Li, Bryden C. Quirk, Peter B. Noble, Rodney W. Kirk, David D. Sampson, Robert A. McLaughlin, "Flexible needle with integrated optical coherence tomography probe for imaging during transbronchial tissue aspiration," Journal of Biomedical Optics 22(10), 106002 (11 October 2017). http://dx.doi.org/10.1117/1.JBO.22.10.106002 Submission: Received 23 June 2017; Accepted 8 September 2017
Submission: Received 23 June 2017; Accepted 8 September 2017
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