10 November 2017 X-ray luminescence computed tomography using a focused x-ray beam
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J. of Biomedical Optics, 22(11), 116004 (2017). doi:10.1117/1.JBO.22.11.116004
Due to the low x-ray photon utilization efficiency and low measurement sensitivity of the electron multiplying charge coupled device camera setup, the collimator-based narrow beam x-ray luminescence computed tomography (XLCT) usually requires a long measurement time. We, for the first time, report a focused x-ray beam-based XLCT imaging system with measurements by a single optical fiber bundle and a photomultiplier tube (PMT). An x-ray tube with a polycapillary lens was used to generate a focused x-ray beam whose x-ray photon density is 1200 times larger than a collimated x-ray beam. An optical fiber bundle was employed to collect and deliver the emitted photons on the phantom surface to the PMT. The total measurement time was reduced to 12.5 min. For numerical simulations of both single and six fiber bundle cases, we were able to reconstruct six targets successfully. For the phantom experiment, two targets with an edge-to-edge distance of 0.4 mm and a center-to-center distance of 0.8 mm were successfully reconstructed by the measurement setup with a single fiber bundle and a PMT.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Wei Zhang, Michael C. Lun, Alex Anh-Tu Nguyen, Changqing Li, "X-ray luminescence computed tomography using a focused x-ray beam," Journal of Biomedical Optics 22(11), 116004 (10 November 2017). https://doi.org/10.1117/1.JBO.22.11.116004 Submission: Received 26 July 2017; Accepted 12 October 2017
Submission: Received 26 July 2017; Accepted 12 October 2017


X-ray imaging

X-ray detectors



Numerical simulations

Computed tomography

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