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5 December 2017 Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice
Jordi L. Tremoleda, Karl Alvarez, Abdirahman Aden, Robert Donnan, Adina T. Michael-Titus, Peter H. Tomlins
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Journal of Biomedical Optics, Vol. 22, Issue 12, 121710 (December 2017). https://doi.org/10.1117/1.JBO.22.12.121710
Abstract
Traumatic brain injury (TBI) results in direct vascular disruption, triggering edema, and reduction in cerebral blood flow. Therefore, understanding the pathophysiology of brain microcirculation following TBI is important for the development of effective therapies. Optical coherence angiography (OCA) is a promising tool for evaluating TBI in rodent models. We develop an approach to OCA that uses the heart-rate frequency to discriminate between static tissue and vasculature. This method operates on intensity data and is therefore not phase sensitive. Furthermore, it does not require spatial overlap of voxels and thus can be applied to pre-existing datasets for which oversampling may not have been explicitly considered. Heart-rate sensitive OCA was developed for dynamic assessment of mouse microvasculature post-TBI. Results show changes occurring at 5-min intervals within the first 50 min of injury.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Jordi L. Tremoleda, Karl Alvarez, Abdirahman Aden, Robert Donnan, Adina T. Michael-Titus, and Peter H. Tomlins "Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice," Journal of Biomedical Optics 22(12), 121710 (5 December 2017). https://doi.org/10.1117/1.JBO.22.12.121710
Received: 31 July 2017; Accepted: 9 November 2017; Published: 5 December 2017
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Cited by 2 scholarly publications.
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KEYWORDS
Traumatic brain injury
Optical coherence tomography
Tissues
Angiography
Coherence (optics)
Heart
Injuries
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