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23 December 2017 Age, ocular magnification, and circumpapillary retinal nerve fiber layer thickness
Mengyu Wang, Tobias Elze, Dian Li, Neda Baniasadi, Kerstin Wirkner, Toralf Kirsten, Joachim Thiery, Markus Löffler, Christoph Engel, Franziska G. Rauscher
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Journal of Biomedical Optics, Vol. 22, Issue 12, 121718 (December 2017). https://doi.org/10.1117/1.JBO.22.12.121718
Abstract
Optical coherence tomography (OCT) manufacturers graphically present circumpapillary retinal nerve fiber layer thickness (cpRNFLT) together with normative limits to support clinicians in diagnosing ophthalmic diseases. The impact of age on cpRNFLT is typically implemented by linear models. cpRNFLT is strongly location-specific, whereas previously published norms are typically restricted to coarse sectors and based on small populations. Furthermore, OCT devices neglect impacts of lens or eye size on the diameter of the cpRNFLT scan circle so that the diameter substantially varies over different eyes. We investigate the impact of age and scan diameter reported by Spectralis spectral-domain OCT on cpRNFLT in 5646 subjects with healthy eyes. We provide cpRNFLT by age and diameter at 768 angular locations. Age/diameter were significantly related to cpRNFLT on 89%/92% of the circle, respectively (pointwise linear regression), and to shifts in cpRNFLT peak locations. For subjects from age 42.1 onward but not below, increasing age significantly decreased scan diameter ( r=−0.28, p<0.001), which suggests that pathological cpRNFLT thinning over time may be underestimated in elderly compared to younger subjects, as scan diameter decrease correlated with cpRNFLT increase. Our detailed numerical results may help to generate various correction models to improve diagnosing and monitoring optic neuropathies.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Mengyu Wang, Tobias Elze, Dian Li, Neda Baniasadi, Kerstin Wirkner, Toralf Kirsten, Joachim Thiery, Markus Löffler, Christoph Engel, and Franziska G. Rauscher "Age, ocular magnification, and circumpapillary retinal nerve fiber layer thickness," Journal of Biomedical Optics 22(12), 121718 (23 December 2017). https://doi.org/10.1117/1.JBO.22.12.121718
Received: 31 July 2017; Accepted: 1 December 2017; Published: 23 December 2017
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KEYWORDS
Optical coherence tomography
Nerve
Eye
Manufacturing
Eye models
Image segmentation
Medical research
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