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23 December 2017 Optical coherence elastography in ophthalmology
Mitchell A. Kirby, Ivan Pelivanov, Shaozhen Song, Lukasz Ambrozinski, Soon Joon Yoon, Liang Gao, David Li, Tueng T. Shen, Ruikang K. Wang, Matthew O'Donnell
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Journal of Biomedical Optics, Vol. 22, Issue 12, 121720 (December 2017). https://doi.org/10.1117/1.JBO.22.12.121720
Abstract
Optical coherence elastography (OCE) can provide clinically valuable information based on local measurements of tissue stiffness. Improved light sources and scanning methods in optical coherence tomography (OCT) have led to rapid growth in systems for high-resolution, quantitative elastography using imaged displacements and strains within soft tissue to infer local mechanical properties. We describe in some detail the physical processes underlying tissue mechanical response based on static and dynamic displacement methods. Namely, the assumptions commonly used to interpret displacement and strain measurements in terms of tissue elasticity for static OCE and propagating wave modes in dynamic OCE are discussed with the ultimate focus on OCT system design for ophthalmic applications. Practical OCT motion-tracking methods used to map tissue elasticity are also presented to fully describe technical developments in OCE, particularly noting those focused on the anterior segment of the eye. Clinical issues and future directions are discussed in the hope that OCE techniques will rapidly move forward to translational studies and clinical applications.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Mitchell A. Kirby, Ivan Pelivanov, Shaozhen Song, Lukasz Ambrozinski, Soon Joon Yoon, Liang Gao, David Li, Tueng T. Shen, Ruikang K. Wang, and Matthew O'Donnell "Optical coherence elastography in ophthalmology," Journal of Biomedical Optics 22(12), 121720 (23 December 2017). https://doi.org/10.1117/1.JBO.22.12.121720
Received: 28 September 2017; Accepted: 15 December 2017; Published: 23 December 2017
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Cited by 156 scholarly publications and 4 patents.
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KEYWORDS
Tissues
Optical coherence tomography
Wave propagation
Cornea
Tissue optics
Elastography
Ophthalmology
CHORUS Article. This article was made freely available starting 23 December 2018
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