22 February 2017 Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins
Author Affiliations +
Abstract
We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4 × 4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [ μ s ( λ ) and μ a ( λ ) ] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x , y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2 × 2    cm 2 area in 9    min . The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibroglandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Brandon S. Nichols, Brandon S. Nichols, Antonio Llopis, Antonio Llopis, Gregory M. Palmer, Gregory M. Palmer, Samuel S. McCachren, Samuel S. McCachren, Ozlem Senlik, Ozlem Senlik, David Miller, David Miller, Martin A. Brooke, Martin A. Brooke, Nan M. Jokerst, Nan M. Jokerst, Joseph Geradts, Joseph Geradts, Rachel Greenup, Rachel Greenup, Nimmi Ramanujam, Nimmi Ramanujam, } "Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins," Journal of Biomedical Optics 22(2), 026007 (22 February 2017). https://doi.org/10.1117/1.JBO.22.2.026007 . Submission: Received: 23 September 2016; Accepted: 26 January 2017
Received: 23 September 2016; Accepted: 26 January 2017; Published: 22 February 2017
JOURNAL ARTICLE
16 PAGES


SHARE
Back to Top