10 February 2017 Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy
Author Affiliations +
Abstract
Existing dosimetric quantities do not fully account for the dynamic interactions between the key components of photodynamic therapy (PDT) or the varying PDT oxygen consumption rates for different fluence rates. Using a macroscopic model, reacted singlet oxygen ( [ O 2 1 ] rx ) was calculated and evaluated for its effectiveness as a dosimetric metric for PDT outcome. Mice bearing radiation-induced fibrosarcoma tumors were treated with benzoporphyrin derivative monoacid ring A (BPD) at a drug-light interval of 3 h with various in-air fluences (30 to 350    J / cm 2 ) and in-air fluence rates (50 to 150    mW / cm 2 ). Explicit measurements of BPD concentration and tissue optical properties were performed and used to calculate [ O 2 1 ] rx , photobleaching ratio, and PDT dose. For four mice, in situ measurements of O 2
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Michele M. Kim, Rozhin Penjweini, Timothy C. Zhu, "Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy," Journal of Biomedical Optics 22(2), 028002 (10 February 2017). https://doi.org/10.1117/1.JBO.22.2.028002 . Submission: Received: 16 December 2016; Accepted: 24 January 2017
Received: 16 December 2016; Accepted: 24 January 2017; Published: 10 February 2017
JOURNAL ARTICLE
10 PAGES


SHARE
Back to Top