1 March 2017 Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography
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Abstract
Influenced by both the intrinsic viscoelasticity of the tissue constituents and the time-evolved redistribution of fluid within the tissue, the biomechanical response of skin can reflect not only localized pathology but also systemic physiology of an individual. While clinical diagnosis of skin pathologies typically relies on visual inspection and manual palpation, a more objective and quantitative approach for tissue characterization is highly desirable. Optical coherence tomography (OCT) is an interferometry-based imaging modality that enables in vivo assessment of cross-sectional tissue morphology with micron-scale resolution, which surpasses those of most standard clinical imaging tools, such as ultrasound imaging and magnetic resonance imaging. This pilot study investigates the feasibility of characterizing the biomechanical response of in vivo human skin using OCT. OCT-based quantitative metrics were developed and demonstrated on the human subject data, where a significant difference between deformed and nondeformed skin was revealed. Additionally, the quantified postindentation recovery results revealed differences between aged (adult) and young (infant) skin. These suggest that OCT has the potential to quantitatively assess the mechanically perturbed skin as well as distinguish different physiological conditions of the skin, such as changes with age or disease.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Pin-Chieh Huang, Pin-Chieh Huang, Paritosh Pande, Paritosh Pande, Ryan L. L. Shelton, Ryan L. L. Shelton, Frank Joa, Frank Joa, Dave Moore, Dave Moore, Elisa Gillman, Elisa Gillman, Kimberly Kidd, Kimberly Kidd, Ryan M. Nolan, Ryan M. Nolan, Mauricio Odio, Mauricio Odio, Andrew Carr, Andrew Carr, Stephen A. Boppart, Stephen A. Boppart, } "Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography," Journal of Biomedical Optics 22(3), 034001 (1 March 2017). https://doi.org/10.1117/1.JBO.22.3.034001 . Submission: Received: 14 November 2016; Accepted: 9 February 2017
Received: 14 November 2016; Accepted: 9 February 2017; Published: 1 March 2017
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