13 February 2017 Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy
Author Affiliations +
Abstract
Although the drug-eluting stent (DES) has dramatically reduced the rate of coronary restenosis, it still occurs in up to 20% of patients with a DES. Monitoring drug delivery could be one way to decrease restenosis rates. We demonstrate real-time photoacoustic imaging and spectroscopy (PAIS) using a wavelength-tunable visible laser and clinical ultrasound scanner to track cardiac drug delivery. The photoacoustic signal was initially calibrated using porcine myocardial samples soaked with a known concentration of a drug surrogate (DiI). Next, an in situ coronary artery was perfused with DiI for 20 min and imaged to monitor dye transport in the tissue. Finally, a partially DiI-coated stent was inserted into the porcine brachiocephalic trunk for imaging. The photoacoustic signal was proportional to the DiI concentration between 2.4 and 120    μ g / ml , and the dye was detected over 1.5 mm from the targeted coronary vessel. Photoacoustic imaging was also able to differentiate the DiI-coated portion of the stent from the uncoated region. These results suggest that PAIS can track drug delivery to cardiac tissue and detect drugs loaded onto a stent with sub-mm precision. Future work using PAIS may help improve DES design and reduce the probability of restenosis.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Kenneth J. Furdella, Kenneth J. Furdella, Russell S. Witte, Russell S. Witte, Jonathan P. Vande Geest, Jonathan P. Vande Geest, } "Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy," Journal of Biomedical Optics 22(4), 041016 (13 February 2017). https://doi.org/10.1117/1.JBO.22.4.041016 . Submission: Received: 15 September 2016; Accepted: 20 January 2017
Received: 15 September 2016; Accepted: 20 January 2017; Published: 13 February 2017
JOURNAL ARTICLE
7 PAGES


SHARE
Back to Top