23 February 2017 Dry coupling for whole-body small-animal photoacoustic computed tomography
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Abstract
We have enhanced photoacoustic computed tomography with dry acoustic coupling that eliminates water immersion anxiety and wrinkling of the animal and facilitates incorporating complementary modalities and procedures. The dry acoustic coupler is made of a tubular elastic membrane enclosed by a closed transparent water tank. The tubular membrane ensures water-free contact with the animal, and the closed water tank allows pressurization for animal stabilization. The dry coupler was tested using a whole-body small-animal ring-shaped photoacoustic computed tomography system. Dry coupling was found to provide image quality comparable to that of conventional water coupling.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Chenghung Yeh, Chenghung Yeh, Lei Li, Lei Li, Liren Zhu, Liren Zhu, Jun Xia, Jun Xia, Chiye Li, Chiye Li, Wanyi Chen, Wanyi Chen, Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Konstantin I. Maslov, Konstantin I. Maslov, Lihong V. Wang, Lihong V. Wang, } "Dry coupling for whole-body small-animal photoacoustic computed tomography," Journal of Biomedical Optics 22(4), 041017 (23 February 2017). https://doi.org/10.1117/1.JBO.22.4.041017 . Submission: Received: 10 August 2016; Accepted: 8 February 2017
Received: 10 August 2016; Accepted: 8 February 2017; Published: 23 February 2017
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