27 April 2017 Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis
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Diffuse optical tomography (DOT) is emerging as a noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in turn, provides a functional information overlay onto the mammographic images, increasing sensitivity and specificity to cancer pathology. We describe a dynamic DOT apparatus designed for tight integration with commercial DBT scanners and providing a fast (up to 1 Hz) image acquisition rate to enable tracking hemodynamic changes induced by the mammographic breast compression. The system integrates 96 continuous-wave and 24 frequency-domain source locations as well as 32 continuous wave and 20 frequency-domain detection locations into low-profile plastic plates that can easily mate to the DBT compression paddle and x-ray detector cover, respectively. We demonstrate system performance using static and dynamic tissue-like phantoms as well as in vivo images acquired from the pool of patients recalled for breast biopsies at the Massachusetts General Hospital Breast Imaging Division.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Bernhard B. Zimmermann, Bernhard B. Zimmermann, Bin Deng, Bin Deng, Bhawana Singh, Bhawana Singh, Mark Martino, Mark Martino, Juliette J. Selb, Juliette J. Selb, Qianqian Fang, Qianqian Fang, Amir Y. Sajjadi, Amir Y. Sajjadi, Jayne A. Cormier, Jayne A. Cormier, Richard H. Moore, Richard H. Moore, Daniel B. Kopans, Daniel B. Kopans, David A. Boas, David A. Boas, Mansi A. Saksena, Mansi A. Saksena, Stefan A. Carp, Stefan A. Carp, } "Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis," Journal of Biomedical Optics 22(4), 046008 (27 April 2017). https://doi.org/10.1117/1.JBO.22.4.046008 . Submission: Received: 15 December 2016; Accepted: 7 April 2017
Received: 15 December 2016; Accepted: 7 April 2017; Published: 27 April 2017

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