5 April 2017 Assessment of intraocular pressure sensing using an implanted reflective flexible membrane
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Glaucoma is a neurodegenerative condition that is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is the main cause for the development of the disease. The symptoms of this form, such as deterioration of vision and scotomas (loss of visual fields), appear in the latter stages of the disease. Therefore, an IOP monitoring device is needed for better, simpler, and faster diagnosis, and to enable a fast treatment response. We present a theoretical assessment as well as preliminary experimental results of a simple approach for easy, optical, IOP self-monitoring. It is based on a polydimethylsiloxane membrane coated with a reflective layer and a Hartmann–Shack wavefront sensor. Nearly linear correlation is found between membrane deformation and Zernike coefficients representing defocus primary spherical aberration, with high sensitivity and negligible dependence on the measurement distance. The proposed device is expected to provide an accurate IOP measurement resolution of less than ± 0.2    mm Hg with a pressure dependence on working distances < 0.7    mm Hg / cm for a thick membrane; the corresponding values for a thin membrane are ± 0.45    mm Hg and < 0.6    mm Hg / cm , respectively, at typical IOP values—up to 40 mm Hg.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Andrey Nazarov, Boris Knyazer, Tova Lifshitz, Mark Schvartzman, Ibrahim Abdulhalim, "Assessment of intraocular pressure sensing using an implanted reflective flexible membrane," Journal of Biomedical Optics 22(4), 047001 (5 April 2017). https://doi.org/10.1117/1.JBO.22.4.047001 . Submission: Received: 26 July 2016; Accepted: 16 March 2017
Received: 26 July 2016; Accepted: 16 March 2017; Published: 5 April 2017

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