Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture

Anouk L. Post; Steven L. Jacques; Henricus J. C. M. Sterenborg; Dirk J. Faber; Ton G. van Leeuwen

doi:10.1117/1.JBO.22.5.050501

22 May 2017 Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture

Anouk L. Post, Steven L. Jacques, Henricus J. C. M. Sterenborg, Dirk J. Faber, Ton G. van Leeuwen

Author Affiliations +

Journal of Biomedical Optics, Vol. 22, Issue 5, 050501 (May 2017). https://doi.org/10.1117/1.JBO.22.5.050501

Abstract

To detect small-scale changes in tissue with optical techniques, small sampling volumes and, therefore, short source–detector separations are required. In this case, reflectance measurements are not adequately described by the diffusion approximation. Previous studies related subdiffusive reflectance to γ or σ, which parameterize the phase function. Recently, it was demonstrated that σ predicts subdiffusive reflectance better than γ, and that σ becomes less predictive for lower numerical apertures (NAs). We derive and evaluate the parameter R_pNA, which incorporates the NA of the detector and the integral of the phase function over the NA in the backward and forward directions. Monte Carlo simulations are performed for overlapping source/detector geometries for a range of phase functions, reduced scattering coefficients, NAs, and source/detector diameters. R_pNA improves prediction of the measured reflectance compared to γ and σ. It is, therefore, expected that R_pNA will improve derivation of optical properties from subdiffusive measurements.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Anouk L. Post, Steven L. Jacques, Henricus J. C. M. Sterenborg, Dirk J. Faber, and Ton G. van Leeuwen "Modeling subdiffusive light scattering by incorporating the tissue phase function and detector numerical aperture," Journal of Biomedical Optics 22(5), 050501 (22 May 2017). https://doi.org/10.1117/1.JBO.22.5.050501

Received: 15 February 2017; Accepted: 2 May 2017; Published: 22 May 2017

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY