13 June 2017 Detection of precancerous lesions in the oral cavity using oblique polarized reflectance spectroscopy: a clinical feasibility study
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J. of Biomedical Optics, 22(6), 065002 (2017). doi:10.1117/1.JBO.22.6.065002
Abstract
We developed a multifiber optical probe for oblique polarized reflectance spectroscopy (OPRS) in vivo and evaluated its performance in detection of dysplasia in the oral cavity. The probe design allows the implementation of a number of methods to enable depth resolved spectroscopic measurements including polarization gating, source–detector separation, and differential spectroscopy; this combination was evaluated in carrying out binary classification tasks between four major diagnostic categories: normal, benign, mild dysplasia (MD), and severe dysplasia (SD). Multifiber OPRS showed excellent performance in the discrimination of normal from benign, MD, SD, and MD plus SD yielding sensitivity/specificity values of 100%/93%, 96%/95%, 100%/98%, and 100%/100%, respectively. The classification of benign versus dysplastic lesions was more challenging with sensitivity and specificity values of 80%/93%, 71%/93%, and 74%/80% in discriminating benign from SD, MD, and SD plus MD categories, respectively; this challenge is most likely associated with a strong and highly variable scattering from a keratin layer that was found in these sites. Classification based on multiple fibers was significantly better than that based on any single detection pair for tasks dealing with benign versus dysplastic sites. This result indicates that the multifiber probe can perform better in the detection of dysplasia in keratinized tissues.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Maria J. Bailey, Nishant Verma, Leonid Fradkin, Sylvia Lam, Calum MacAulay, Catherine Poh, Mia K. Markey, Konstantin V. Sokolov, "Detection of precancerous lesions in the oral cavity using oblique polarized reflectance spectroscopy: a clinical feasibility study," Journal of Biomedical Optics 22(6), 065002 (13 June 2017). http://dx.doi.org/10.1117/1.JBO.22.6.065002 Submission: Received 6 March 2017; Accepted 18 May 2017
Submission: Received 6 March 2017; Accepted 18 May 2017
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KEYWORDS
Optical fibers

Scattering

Diagnostics

Tissues

Spectroscopy

Polarization

Reflectance spectroscopy

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