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17 July 2017 Photoacoustic imaging using genetically encoded reporters: a review
Joanna Brunker, Junjie Yao, Jan Laufer, Sarah E. Bohndiek
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Journal of Biomedical Optics, Vol. 22, Issue 7, 070901 (July 2017). https://doi.org/10.1117/1.JBO.22.7.070901
Abstract
Genetically encoded contrast in photoacoustic imaging (PAI) is complementary to the intrinsic contrast provided by endogenous absorbing chromophores such as hemoglobin. The use of reporter genes expressing absorbing proteins opens the possibility of visualizing dynamic cellular and molecular processes. This is an enticing prospect but brings with it challenges and limitations associated with generating and detecting different types of reporters. The purpose of this review is to compare existing PAI reporters and signal detection strategies, thereby offering a practical guide, particularly for the nonbiologist, to choosing the most appropriate reporter for maximum sensitivity in the biological and technological system of interest.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
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Joanna Brunker, Junjie Yao, Jan Laufer, and Sarah E. Bohndiek "Photoacoustic imaging using genetically encoded reporters: a review," Journal of Biomedical Optics 22(7), 070901 (17 July 2017). https://doi.org/10.1117/1.JBO.22.7.070901
Received: 12 April 2017; Accepted: 12 June 2017; Published: 17 July 2017
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Cited by 74 scholarly publications and 1 patent.
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KEYWORDS
Photoacoustic imaging
Biological detection systems
Chromophores
Proteins
Signal detection
Visualization
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