6 July 2017 Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography
Author Affiliations +
Abstract
Diseases that cause hearing loss and/or vertigo in humans such as Meniere’s disease are often studied using animal models. The volume of endolymph within the inner ear varies with these diseases. Here, we used a mouse model of increased endolymph volume, endolymphatic hydrops, to develop a computer-aided objective approach to measure endolymph volume from images collected in vivo using optical coherence tomography. The displacement of Reissner’s membrane from its normal position was measured in cochlear cross sections. We validated our computer-aided measurements with manual measurements and with trained observer labels. This approach allows for computer-aided detection of endolymphatic hydrops in mice, with test performance showing sensitivity of 91% and specificity of 87% using a running average of five measurements. These findings indicate that this approach is accurate and reliable for classifying endolymphatic hydrops and quantifying endolymph volume.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
George S. Liu, Jinkyung Kim, Brian E. Applegate, John S. Oghalai, "Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography," Journal of Biomedical Optics 22(7), 076002 (6 July 2017). https://doi.org/10.1117/1.JBO.22.7.076002 . Submission: Received: 13 April 2017; Accepted: 13 June 2017
Received: 13 April 2017; Accepted: 13 June 2017; Published: 6 July 2017
JOURNAL ARTICLE
10 PAGES


SHARE
Back to Top