11 July 2017 Gadolinium/terbium hybrid macromolecular complexes for bimodal imaging of atherothrombosis
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Abstract
We developed a fluorescence imaging microscope system intended for the localization within artery slices of a gadolinium-based macromolecular biospecific magnetic resonance (MR) contrast agent used for the visualization of atherothrombosis. As the contrast agent is not initially fluorescent, we substitute some gadolinium ions for terbium ions to make them fluorescent while preserving their chemical characteristics. A long fluorescence emission time constant enables us to have a suitable signal-to-noise ratio, despite a low intensity, using pulsed illumination and time-gated imaging. Images of rat arteries show that the contrast agent is indeed localized on the specific regions of the tissues. We currently have a tool that allows us to understand and optimize the MR contrast agent.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Nguyen Trong Nghia, Eric Tinet, Dominique Ettori, Anne Beilvert, Graciela Pavon-Djavid, Murielle Maire, Phalla Ou, Jean-Michel Tualle, Frédéric Chaubet, "Gadolinium/terbium hybrid macromolecular complexes for bimodal imaging of atherothrombosis," Journal of Biomedical Optics 22(7), 076004 (11 July 2017). https://doi.org/10.1117/1.JBO.22.7.076004 . Submission: Received: 24 January 2017; Accepted: 15 June 2017
Received: 24 January 2017; Accepted: 15 June 2017; Published: 11 July 2017
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