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11 July 2017 Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins
Nicusor Iftimia, Oriol Yélamos, Chih-Shan J. Chen, Gopi Maguluri, Miguel A. Cordova, Aditi Sahu, Jesung Park, William Fox, Christi Alessi-Fox, Milind Rajadhyaksha
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Journal of Biomedical Optics, Vol. 22, Issue 7, 076006 (July 2017). https://doi.org/10.1117/1.JBO.22.7.076006
Abstract
We present a hand-held implementation and preliminary evaluation of a combined optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) probe for detecting and delineating the margins of basal cell carcinomas (BCCs) in human skin in vivo. A standard OCT approach (spectrometer-based) with a central wavelength of 1310 nm and 0.11 numerical aperture (NA) was combined with a standard RCM approach (830-nm wavelength and 0.9 NA) into a common path hand-held probe. Cross-sectional OCT images and enface RCM images are simultaneously displayed, allowing for three-dimensional microscopic assessment of tumor morphology in real time. Depending on the subtype and depth of the BCC tumor and surrounding skin conditions, OCT and RCM imaging are able to complement each other, the strengths of each helping overcome the limitations of the other. Four representative cases are summarized, out of the 15 investigated in a preliminary pilot study, demonstrating how OCT and RCM imaging may be synergistically combined to more accurately detect BCCs and more completely delineate margins. Our preliminary results highlight the potential benefits of combining the two technologies within a single probe to potentially guide diagnosis as well as treatment of BCCs.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Nicusor Iftimia, Oriol Yélamos, Chih-Shan J. Chen, Gopi Maguluri, Miguel A. Cordova, Aditi Sahu, Jesung Park, William Fox, Christi Alessi-Fox, and Milind Rajadhyaksha "Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins," Journal of Biomedical Optics 22(7), 076006 (11 July 2017). https://doi.org/10.1117/1.JBO.22.7.076006
Received: 17 May 2017; Accepted: 20 June 2017; Published: 11 July 2017
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KEYWORDS
Optical coherence tomography
Confocal microscopy
Reflectivity
Skin
Tumors
3D displays
3D image processing
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