11 July 2017 Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection
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Abstract
5-Aminolevelunic acid-induced protoporphyrin IX (PpIX) fluorescence-guided resection (FGR) enables maximum safe resection of glioma by providing real-time tumor contrast. However, the subjective visual assessment and the variable intrinsic optical attenuation of tissue limit this technique to reliably delineating only high-grade tumors that display strong fluorescence. We have previously shown, using a fiber-optic probe, that quantitative assessment using noninvasive point spectroscopic measurements of the absolute PpIX concentration in tissue further improves the accuracy of FGR, extending it to surgically curable low-grade glioma. More recently, we have shown that implementing spatial frequency domain imaging with a fluorescent-light transport model enables recovery of two-dimensional images of [PpIX], alleviating the need for time-consuming point sampling of the brain surface. We present first results of this technique modified for
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Mira Sibai, Carl Fisher, Israel Veilleux, Jonathan T. Elliott, Frederic Leblond, David W. Roberts, Brian C. Wilson, "Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection," Journal of Biomedical Optics 22(7), 076007 (11 July 2017). https://doi.org/10.1117/1.JBO.22.7.076007 . Submission: Received: 23 January 2017; Accepted: 21 June 2017
Received: 23 January 2017; Accepted: 21 June 2017; Published: 11 July 2017
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