11 July 2017 Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection
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Abstract
5-Aminolevelunic acid-induced protoporphyrin IX (PpIX) fluorescence-guided resection (FGR) enables maximum safe resection of glioma by providing real-time tumor contrast. However, the subjective visual assessment and the variable intrinsic optical attenuation of tissue limit this technique to reliably delineating only high-grade tumors that display strong fluorescence. We have previously shown, using a fiber-optic probe, that quantitative assessment using noninvasive point spectroscopic measurements of the absolute PpIX concentration in tissue further improves the accuracy of FGR, extending it to surgically curable low-grade glioma. More recently, we have shown that implementing spatial frequency domain imaging with a fluorescent-light transport model enables recovery of two-dimensional images of [PpIX], alleviating the need for time-consuming point sampling of the brain surface. We present first results of this technique modified for
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Mira Sibai, Mira Sibai, Carl Fisher, Carl Fisher, Israel Veilleux, Israel Veilleux, Jonathan T. Elliott, Jonathan T. Elliott, Frederic Leblond, Frederic Leblond, David W. Roberts, David W. Roberts, Brian C. Wilson, Brian C. Wilson, } "Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection," Journal of Biomedical Optics 22(7), 076007 (11 July 2017). https://doi.org/10.1117/1.JBO.22.7.076007 . Submission: Received: 23 January 2017; Accepted: 21 June 2017
Received: 23 January 2017; Accepted: 21 June 2017; Published: 11 July 2017
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