4 August 2017 Measurement of tissue-radiation dosage using a thermal steady-state elastic shear wave
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A biodosimeter based on thermal-induced elastic shear wave (TIESW) in silicone acellular porcine dermis (SAPD) at thermal steady state has been proposed and demonstrated. A square slab SAPD treated with ionizing radiation was tested. The SAPD becomes a continuous homogeneous and isotropic viscoelastic medium due to the generation of randomly coiled collagen fibers formed from their bundle-like structure in the dermis. A harmonic TIESW then propagates on the surface of the SAPD as measured by a nanometer-scaled strain-stress response under thermal equilibrium conditions at room temperature. TIESW oscillation frequency was noninvasively measured in real time by monitoring the transverse displacement of the TIESW on the SAPD surface. Because the elastic shear modulus is highly sensitive to absorbed doses of ionizing radiation, this proposed biodosimeter can become a highly sensitive and noninvasive method for quantitatively determining tissue-absorbed dosage in terms of TIESW’s oscillation frequency. Detection sensitivity at 1 cGy and dynamic ranges covering 1 to 40 cGy and 80 to 500 cGy were demonstrated.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Sheng-Yi Chang, Sheng-Yi Chang, Tong-Sheng Hsieh, Tong-Sheng Hsieh, Wei-Ru Chen, Wei-Ru Chen, Jin-Chung Chen, Jin-Chung Chen, Chien Chou, Chien Chou, } "Measurement of tissue-radiation dosage using a thermal steady-state elastic shear wave," Journal of Biomedical Optics 22(8), 085001 (4 August 2017). https://doi.org/10.1117/1.JBO.22.8.085001 . Submission: Received: 15 January 2017; Accepted: 10 July 2017
Received: 15 January 2017; Accepted: 10 July 2017; Published: 4 August 2017

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