31 May 2017 Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing
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Abstract
Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-and-error approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Emil Sobol, Emil Sobol, Olga Baum, Olga Baum, Anatoly Shekhter, Anatoly Shekhter, Sebastian Wachsmann-Hogiu, Sebastian Wachsmann-Hogiu, Alexander Shnirelman, Alexander Shnirelman, Yulia Alexandrovskaya, Yulia Alexandrovskaya, Ivan Sadovskyy, Ivan Sadovskyy, Valerii Vinokur, Valerii Vinokur, } "Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing," Journal of Biomedical Optics 22(9), 091515 (31 May 2017). https://doi.org/10.1117/1.JBO.22.9.091515 . Submission: Received: 29 November 2016; Accepted: 28 April 2017
Received: 29 November 2016; Accepted: 28 April 2017; Published: 31 May 2017
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